When I see this one, I always picture that fun scene from the musical “Bye, Bye, Birdie!” But it’s a great option for anyone who loves vintage things – especially the good ol’ days of landlines. If you’ve got some old phones lying around in the attic, know a good thrift store that always has some on hand, or just love decorating with something just a little different, then you’ll love this telephone bookend set. Via A Beautiful Mess Telephone Bookends Source You just need a few inexpensive supplies from the hardware store, a handsaw, and a little bit of time for this fun, quick, and easy project that will make that bookshelf pop. It was originally inspired by a penholder, so even more useful, if you happen to keep those books in the office. If you want a unique bookend set that will stand out from the rest, while still being inexpensive and easy, then you just might love this faux gold pipe bookends set. Via A Beautiful Mess Faux Gold Pipes Bookends Source You just need a few things, including pretty books you won’t be reading (thrift stores are great for this). Or, you could follow a simple tutorial and create theses invisible bookends from old discarded books instead. You can stack a pile of heavy books at one end to keep the others from falling down. You can grab a rock from the garden and shove it onto the shelf. There are a ton of different ways of getting your books to stay in place. So instead of spending hours scouring online catalogs, you could just make your own from any of the simple to follow tutorials below. The right color, the right texture, the right style – they can all be so elusive. are coinventors on a provisional patent application that incorporates discoveries described in this manuscript.If you’re a book lover, then you know that bookends are a must-have for any library.īut finding ones that you like – or choose to actually spend that kind of money on – can be rare. Our approach now enables targeted design of binders to sites of interest on a wide variety of proteins for therapeutic and diagnostic applications. Experimental data on nearly half a million computational designs and hundreds of thousands of point mutants provide detailed feedback on the strengths and limitations of the method and of our current understanding of protein-protein interactions, and should guide improvement of both. We succeeded in solving crystal structures of four of the binder-target complexes, and all four are very close to the corresponding computational design models. Biophysical characterization shows that the binders, which are all smaller than 65 amino acids, are hyperstable and bind their targets with nanomolar to picomolar affinities. We demonstrate its very broad applicability by de novo design of binding proteins to 12 diverse protein targets with very different shapes and surface properties. We describe a general solution to this problem which starts with a broad exploration of the very large space of possible binding modes and interactions, and then intensifies the search in the most promising regions. The design of proteins that bind to a specific site on the surface of a target protein using no information other than the three-dimensional structure of the target remains an outstanding challenge.
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